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My approach to mentoring and training was founded on recognizing the importance of interactive and captivating learning encounters for both mentees and students. This method not only enabled a deeper grasp of the subject matter but also sparked critical thinking and a true enthusiasm for learning. Employing
techniques like active participation, visual aids, and hands-on activities allowed me to cater to various learning preferences and establish an inclusive atmosphere. This inclusiveness is essential for reaching all individuals and optimizing the learning capabilities of my students.
1) Biolyse Pharma – Research Scientist
2) University of Toronto - Postdoctoral Fellow
3) University of Leicester - Postdoctoral Fellow
My research focuses on the interface of cancer immunology, therapeutic development, and translational medicine. I am broadly interested in understanding mechanisms of immune regulation within the tumor microenvironment, with particular emphasis on immune evasion, chemokine signaling, and macrophage recruitment. A central aspect of my work is the development and optimization of biotherapeutics, including monoclonal antibodies, biosimilars, gene- and cell-based therapies, and innovative drug delivery systems. I also integrate bioinformatics and molecular profiling approaches to identify biomarkers of disease progression and therapeutic response, with the ultimate goal of advancing novel immunotherapies and improving patient outcomes.
Molecular Biology
Medical Virology
• Sami Mamand, Rebecca L Allchin, Matthew J Ahearne, Simon D Wagner. Comparison of interleukin-2-inducible kinase (ITK) inhibitors and potential for combination therapies for T-cell lymphoma. Scientific Reports 8 (1), 14216. 2018.
• Katherine Wickenden, Nadia Nawaz, Sami Mamand, Deevia Kotecha, Amy L Wilson, Simon D Wagner, Matthew J Ahearne. PD1hi cells associate with clusters of proliferating B-cells in marginal zone lymphoma. Diagnostic Pathology 13, 1-10. 2018.
• Rebecca L. Allchin, Michael E. Kelly, Sami Mamand, Anthony G. Doran, Thomas Keane, Matthew J. Ahearne and Simon D. Wagne. Structural and diffusion weighted MRI demonstrates responses to ibrutinib in a mouse model of follicular helper (Tfh) T-cell lymphoma. PLOS ONE 14 (e0215765). 2019.
• Sami Mamand, Matthew Carr, Rebecca L. Allchin, Matthew J. Ahearne and Simon D. Wagner. Interleukin-2–inducible T-cell kinase inhibitors modify functional polarization of human peripheral T-cell lymphoma cells. blood advances 3 (5), 705-710. 2019.
• Simon D. Wagner Barbara Ottolini, Nadia Nawaz, Christopher S. Trethewey, Sami Mamand, Rebecca L. Allchin, Richard Dillon, Paul A. Fields, Matthew J. Ahearne. Multiple mutations at exon 2 of RHOA detected in plasma from patients with peripheral T cell lymphoma. blood advances 4 (11), 2392–2403. 2020.
• Matthew Carr, Sami Mamand, Kathryn L. Chapman, Trevor Perrior, Simon D. Wagner. IKKε and TBK1 in diffuse large B-cell lymphoma: a possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF-κB and IL-10 signalling. Journal of Cellular and Molecular Medicine. 2020.
• Roberto J. Botelho Golam T. Saffi, Evan TangID , Sami Mamand, Subothan Inpanathan, Aaron Fountain, Leonardo Salmena. Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition. PLOS ONE 16 (11), 36. 2021.
• Boutry, Laura F DiGiovanni, Nicholas Demers, Aaron Fountain, Sami Mamand, Roberto J Botelho, Peter K Kim. Arf1-PI4KIIIβ positive vesicles regulate PI (3) P signaling to facilitate lysosomal tubule fission Maxime. Journal of Cell Biology 222 (9), e202205128. 2023.
• Suppression of Class Switch Recombination to IgA by RASA2 and RASA3 through inhibition of TGF-β signaling. Sami Mamand, Mohammed Kashem, Heather Liu, Alberto Martin. The Journal of Immunology, October 2024.
• Sami Mamand, Sarkar Azeez, Raya Yashooa, Christer Janson. Advancing CAR-Cell Therapies for Solid Tumours: Challenges, Therapeutic Strategies, and Perspectives. The Journal of Molecular Cancer, July 2025.
• Yuqing Feng, Philip Barbulescu, Chetan Chana, Melika Shirdarreh, Hong Yang, Lizhen Wu, Sami Mamand, Mohammad Kashem, Amin Zia6, Ming Han, Julissa Tsao, Trevor Pugh, David Cescon, David D. Schatz, Frank Sicheri, Alberto Martin, Rossanna C. Pezo. FAM72A promotes UNG2 degradation and mutagenesis in human cancer cells. The Journal of Scientific Reports, July 2025.